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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 19, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Plasmacytoid dendritic cells: physiologic roles and pathologic states.

Armin G Jegalian1, Fabio Facchetti, Elaine S Jaffe

  • 1Laboratory of Pathology, Hematopathology Section, National Cancer Institute, Bethesda, MD, USA.

Advances in Anatomic Pathology
|October 24, 2009
PubMed
Summary

Plasmacytoid dendritic cells (PDCs) are key immune cells producing interferon-alpha. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematopoietic neoplasm distinct from lymphoma, treatable with leukemia regimens.

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Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

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Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
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Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

  • Immunology
  • Hematopathology
  • Oncology

Background:

  • Plasmacytoid dendritic cells (PDCs) are rare peripheral blood cells (<0.1%) crucial for interferon-alpha production.
  • PDCs link innate and adaptive immunity, with roles in antigen presentation and accumulation during inflammation and malignancy.
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive malignancy previously misclassified.

Purpose of the Study:

  • To clarify the nature and classification of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN).
  • To differentiate BPDCN from lymphomas and other myeloid neoplasms.
  • To discuss current therapeutic approaches and prognosis for BPDCN.

Main Methods:

  • Review of pathological and clinical data on PDCs and BPDCN.
  • Immunophenotypic and genetic analysis of BPDCN cases.
  • Comparison of BPDCN with lymphomas and other hematopoietic neoplasms.

Main Results:

  • BPDCN is a distinct precursor hematopoietic neoplasm, not a lymphoma.
  • BPDCN lacks Epstein-Barr virus association, distinguishing it from natural killer cell lymphomas.
  • Acute leukemia therapy and bone marrow transplantation show potential for BPDCN remission and cure.

Conclusions:

  • BPDCN represents a unique neoplastic entity arising from plasmacytoid dendritic cell precursors.
  • Accurate classification is crucial for appropriate treatment selection.
  • Leukemia-oriented therapy offers promising outcomes for BPDCN patients.