Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

When to randomize?

S Durrleman1, R Simon

  • 1Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative strain typing of Rhizobium leguminosarum bv. viciae natural populations.

Canadian journal of microbiology·2001
Same author

Impact of 2,4-diacetylphloroglucinol-producing biocontrol strain Pseudomonas fluorescens F113 on intraspecific diversity of resident culturable fluorescent pseudomonads associated with the roots of field-grown sugar beet seedlings.

Applied and environmental microbiology·2001
Same author

Distal chromosome 17 gains in neuroblastomas detected by comparative genomic hybridization (CGH) are associated with a poor clinical outcome.

Medical and pediatric oncology·2001
Same author

Control of cell fate in plant meristems.

Novartis Foundation symposium·2001
Same author

A molecular link between stem cell regulation and floral patterning in Arabidopsis.

Cell·2001
Same author

Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes.

Cancer research·2001
Same journal

Biology Over Monotherapy: Mature Results From European Organisation For Research and Treatment of Cancer 22033-26033 Reaffirm Molecular Stratification, Not Treatment Sequence, Defines Prognosis in Low-Grade Glioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same journal

Risk Prognostication After Hypomethylating Agents Combined With Venetoclax in AML: The PRISM Risk Model.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same journal

Temozolomide Versus Radiotherapy as First-Line Therapy for Low-Grade Glioma: Mature Results of a Randomized Phase III Trial (EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTU).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same journal

Efficacy and Tolerability of Zenocutuzumab in Advanced <i>NRG1</i> Fusion-Positive Cholangiocarcinoma: Results From the eNRGy Phase II Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same journal

Phase I/II Study of Sonrotoclax (BGB-11417) Monotherapy in Patients With Mantle Cell Lymphoma Previously Treated With Anti-CD20 Therapy and a Bruton Tyrosine Kinase Inhibitor.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same journal

Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
See all related articles

Determining the optimal timing for randomization in clinical trials is complex. This study offers a tool to help researchers decide when to randomize, balancing statistical principles with practical study needs.

Area of Science:

  • Clinical Trials Methodology
  • Biostatistics
  • Medical Research Design

Background:

  • Clinical trials frequently investigate optimal therapy duration or the benefit of adding consolidation/maintenance regimens.
  • The timing of randomization is a critical, often challenging, aspect of trial design.

Purpose of the Study:

  • To analyze factors influenced by the timing of randomization in clinical trials.
  • To quantify the impact of randomization timing on study outcomes.
  • To develop a practical tool for investigators and statisticians to determine optimal randomization timing.

Main Methods:

  • Review of statistical principles regarding randomization timing.
  • Analysis of factors affected by different randomization schedules.
  • Development and presentation of a decision-making framework.

Related Experiment Videos

Main Results:

  • Identified key factors influenced by randomization timing.
  • Quantified the effects of early versus late randomization.
  • Proposed a systematic approach to selecting randomization timing.

Conclusions:

  • The timing of randomization significantly impacts clinical trial design and outcomes.
  • A flexible approach, guided by specific study factors, is necessary.
  • The provided tool aids in making informed decisions about randomization timing.