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Formation of biodegradable microcapsules utilizing 3D, selectively surface-modified PDMS microfluidic devices.

Chung-Yu Liao1, Yu-Chuan Su

  • 1Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan.

Biomedical Microdevices
|October 24, 2009
PubMed
Summary

Researchers created biodegradable microcapsules using polydimethylsiloxane (PDMS) microfluidic devices. These microcapsules can encapsulate materials for controlled delivery in biological and pharmaceutical applications.

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Area of Science:

  • Biomaterials Science
  • Microfluidics
  • Drug Delivery

Background:

  • Biodegradable microcapsules are crucial for controlled release applications.
  • Microfluidic devices offer precise control over microcapsule fabrication.

Purpose of the Study:

  • To develop biodegradable microcapsules using polydimethylsiloxane (PDMS) double-emulsification devices.
  • To demonstrate the controlled fabrication of monodisperse water-in-organic-solvent-in-water (W/O/W) emulsions.
  • To explore the potential of these microcapsules for controlled delivery systems.

Main Methods:

  • Utilized 3D PDMS microchannels with photografting for surface modification.
  • Employed a double-emulsification technique (W/O/W) to form emulsions.
  • Adjusted fluid flow rates to control emulsion dimensions.

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  • Dissolved biodegradable polymers (poly(L-lactic acid), trilaurin, phosphocholine) in ethyl acetate and extracted solvent to form microcapsules.
  • Incorporated gamma-Fe(2)O(3) nanoparticles for electromagnetic responsiveness.

    • Main Results:

    • Successfully fabricated monodisperse W/O/W emulsions.
    • Produced biodegradable microcapsules composed of poly(L-lactic acid), trilaurin, and phosphocholine.
    • Demonstrated simultaneous embedding of gamma-Fe(2)O(3) nanoparticles, imparting electromagnetic responsiveness.
    • Showcased tunable microcapsule dimensions via flow rate adjustments.

    Conclusions:

    • PDMS microfluidic devices are versatile for fabricating biodegradable microcapsules.
    • The fabricated microcapsules show promise as controlled delivery systems.
    • Potential applications exist in biological and pharmaceutical fields, including targeted drug delivery.