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A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands
Trine P Petersen1, Andreas Ritzén, Trond Ulven
1Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Organic Letters
|October 27, 2009
Abstract:
A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.
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