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Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Multi-gram scale synthesis of FR180204
Samarjit Patnaik1, Harry C Dietz, Wei Zheng
1National Institutes of Health Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850, USA. patnaiks@mail.nih.gov
The Journal of Organic Chemistry
|October 27, 2009
Summary
A new, six-step synthesis for the ERK inhibitor FR180204 has been developed. This efficient method allows for the production of multi-gram quantities of FR180204 for research purposes.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- Extracellular signal-regulated kinase (ERK) pathways are crucial in cellular signaling.
- Dysregulation of ERK pathways is implicated in various diseases, including cancer.
- FR180204 is a known inhibitor of ERK pathways.
Purpose of the Study:
- To develop an efficient and scalable synthetic route for the ERK inhibitor FR180204.
- To provide a reliable method for producing multi-gram quantities of FR180204.
Main Methods:
- A concise, six-step synthetic strategy was designed and executed.
- The synthesis focused on operational simplicity and scalability.
Main Results:
- Successful synthesis of FR180204 was achieved.
- The developed route is operationally simple and yields multi-gram quantities.
- This synthesis provides a practical method for obtaining FR180204.
Conclusions:
- A streamlined and scalable synthesis for FR180204 has been established.
- This method facilitates the availability of FR180204 for further biological investigation.
- The developed synthetic route is suitable for producing significant quantities of the ERK inhibitor.
