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Published on: June 6, 2017
Next-generation 9216-microwell cell arrays for high-content screening microscopy.
Jürgen Reymann1, Nina Beil, Jürgen Beneke
1ViroQuant-CellNetworks RNAi Screening Facility, BioQuant, University of Heidelberg, Germany.
Biotechniques
|October 27, 2009
Summary
We developed novel 9216-microwell cell arrays for high-throughput mammalian cell transfection. This method merges multiwell plate and cell microarray benefits for efficient cell-based screening.
Area of Science:
- Biotechnology
- Cell Biology
- Microscopy
Background:
- Reverse transfection is a key method for high-throughput screening using mammalian cells.
- Existing cell array methods offer high density but may lack sample separation.
- Multiwell plates provide sample separation but lower density.
Purpose of the Study:
- To introduce novel 9216-microwell cell arrays.
- To combine the advantages of multiwell plates and cell microarrays.
- To facilitate high-content screening applications.
Main Methods:
- Development of 9216-microwell cell arrays.
- Implementation of reverse transfection protocols on these arrays.
- Utilizing the arrays for parallel mammalian cell transfection.
Main Results:
- The novel arrays successfully enabled parallel transfection of mammalian cells.
- The design integrates physical sample separation with high sample density.
- The arrays support long-term storage of cell samples.
Conclusions:
- The 9216-microwell cell arrays represent an advancement in high-throughput cell-based assays.
- This technology enhances efficiency and sample management in cell screening.
- The arrays are suitable for various applications in cell biology and drug discovery.
