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HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage

Luca Vanella1, Dong Hyun Kim, David Asprinio

  • 1Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA.

Bone
|October 27, 2009
PubMed
Summary

Heme oxygenase-1 (HO-1) upregulation promotes osteoblast differentiation in human bone marrow mesenchymal stem cells (MSC). Conversely, decreased HO-1 or high glucose levels drive MSC toward adipogenesis, suggesting HO-1 as a target for osteoporosis treatment.

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