Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electrophysiologic evidence of loss of consciousness in cattle during slaughter with and without stunning: a systematic review and methodological overview.

Frontiers in veterinary science·2026

Same author

Pulsed focused ultrasound for seizure suppression: Mechanisms, models, and clinical translation.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

Same author

Efficacy and Safety of Domperidone for Patients With Symptoms of Gastroparesis; Long-Term Results.

Neurogastroenterology and motility·2026

Same author

Visually-provoked seizures: Consensus of the Epilepsy Foundation Working Group.

Epilepsia·2025

Same author

Treatments for Functional Neurological Disorder: A Practical Guide for Program Development.

The Journal of neuropsychiatry and clinical neurosciences·2025

Same author

Focal Spikes Versus Sharp Waves: Do They Differ?

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2025

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Therapeutic brain stimulation for epilepsy.

Juliana Lockman¹, Robert S Fisher¹

¹Department of Neurology and Neurological Sciences, Room A343, 300 Pasteur Drive, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.

Neurologic Clinics

|October 27, 2009

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) shows promise for epilepsy treatment, with a recent trial demonstrating efficacy for partial seizures. Further research is needed to optimize parameters and identify ideal candidates for this palliative therapy.

More Related Videos

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Area of Science:

Neurology
Neurosurgery
Epileptology

Background:

Deep brain stimulation (DBS) has been explored for epilepsy for over 30 years.
Success of vagus nerve stimulation for epilepsy and DBS for movement disorders fuels interest.
Clinical exploration includes various brain regions like the thalamus, hippocampus, and cerebellum.

Purpose of the Study:

To review the current status and future challenges of brain stimulation therapies for epilepsy.
To evaluate the efficacy of different brain targets for DBS in epilepsy treatment.
To discuss the potential of DBS as a therapeutic option for intractable epilepsy.

Main Methods:

Review of existing literature, including animal models and clinical studies.
Analysis of results from small, uncontrolled studies and a pivotal large, double-blind controlled trial.
Examination of ongoing and planned clinical trials for brain stimulation in epilepsy.

Main Results:

A large controlled trial demonstrated the efficacy of anterior nucleus of the thalamus DBS for partial seizures.
DBS has shown variable efficacy across different brain regions in animal models.
Small, uncontrolled studies present limitations in interpreting clinical efficacy.

Conclusions:

Deep brain stimulation (DBS) is emerging as a clinically useful therapy for certain types of epilepsy.
Optimal stimulation parameters and patient selection criteria require further investigation.
DBS offers a palliative, rather than curative, option for some individuals with treatment-resistant epilepsy.