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A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity

Lalitha Madhavan1, Timothy J Collier

  • 1Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA. madhavla@ucmail.uc.edu

Neuropharmacology
|October 27, 2009
PubMed

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.