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HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8

Susana T Valente1, Greg M Gilmartin, Krishnan Venkatarama

  • 1Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, NY 10032, USA. svalente@scripps.edu

Molecular Cell
|October 27, 2009
PubMed
Summary

The N-terminal 91 amino acids of eukaryotic initiation factor 3 subunit f (N91-eIF3f) inhibit HIV-1 replication by blocking pre-mRNA 3' end processing. This process involves eIF3f, 9G8, and CDK11, impacting viral gene expression.

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