Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antioxidants and aging.

R G Cutler1

  • 1Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224.

The American Journal of Clinical Nutrition
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Longevity determinant genes may control aging. Higher antioxidant levels and lower oxidative DNA damage correlate with longer mammalian lifespans, suggesting antioxidants influence aging and healthspan.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Superoxide dismutase, thermal respiratory acclimation, and growth in an earthworm, Eisenia foetida.

Growth·2013
Same author

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women.

International journal of obesity (2005)·2010
Same author

Effect of dietary restriction on serum antioxidant capacity in rats.

Archives of gerontology and geriatrics·2008
Same author

Associative and predictive biomarkers of dementia in HIV-1-infected patients.

Neurology·2007
Same author

Differential response induced by exposure to low-dose ionizing radiation in SHSY-5Y and normal human fibroblast cells.

Applied biochemistry and biotechnology·2006
Same author

Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia.

Neurology·2004
Same journal

Associations of red blood cell fatty acids with personality traits: 10-year follow-up in the Kibbutzim Family Study.

The American journal of clinical nutrition·2026
Same journal

Corrigendum to: Vitamin D status and breast cancer in Saudi Arabian women: case-control study [Am J Clin Nutr 98 (2013) 105-110].

The American journal of clinical nutrition·2026
Same journal

High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

The American journal of clinical nutrition·2026
Same journal

Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

The American journal of clinical nutrition·2026
Same journal

Reframing Basic Experimental Studies in Humans-Implications for Nutrition Science.

The American journal of clinical nutrition·2026
Same journal

Inconvenient for the investigator but convenient for science: trial registration in The American Journal of Clinical Nutrition.

The American journal of clinical nutrition·2026
See all related articles

Area of Science:

  • Gerontology and molecular biology
  • Biochemistry and oxidative stress research

Background:

  • Aging is a complex biological process influenced by metabolic and developmental factors.
  • Experimental data suggests a significant role for oxyradicals in the aging process.
  • The existence of specific longevity determinant genes (LDGs) governing aging rate is hypothesized.

Purpose of the Study:

  • To test the hypothesis that antioxidants function as longevity determinant genes (LDGs).
  • To investigate the correlation between antioxidant levels, oxidative stress, and mammalian lifespan.

Main Methods:

  • Assessed tissue concentrations of specific antioxidants (superoxide dismutase, carotenoids, alpha-tocopherol, uric acid) in mammals.
  • Measured tissue resistance to spontaneous autoxidation.

Related Experiment Videos

  • Quantified oxidative damage to DNA.

    • Main Results:

    • A positive correlation was observed between tissue antioxidant concentrations and mammalian lifespan.
    • Tissue resistance to autoxidation and DNA oxidative damage showed an inverse correlation with lifespan.
    • Specific antioxidants like superoxide dismutase, carotenoids, alpha-tocopherol, and uric acid were linked to longevity.

    Conclusions:

    • Oxyradicals play a role in the aging process.
    • Antioxidant status is a key factor in determining the frequency of age-dependent diseases.
    • Maintaining adequate antioxidant levels may prolong general health and influence lifespan.