Related Experiment Video
Updated: Jun 19, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
Published on: March 30, 2020
The capsule drug device: novel approach for drug delivery to the eye
Sarah A Molokhia1, Himanshu Sant, Jacquelyn Simonis
1Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. s.a.molokhia@utah.edu
Abstract:
Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semi-permeable membrane for controlled delivery and silicone check valves for refilling. The device showed near zero-order release kinetics and Avastin stability was investigated with accelerated temperature studies.
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