Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake and Energy Expenditure in Diet-Induced Obese Rats.

International journal of molecular sciences·2025

Same author

Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats.

Frontiers in endocrinology·2025

Same author

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats.

Frontiers in drug delivery·2025

Same author

The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake and Energy Expenditure in Diet-Induced Obese Rats.

bioRxiv : the preprint server for biology·2025

Same author

Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats.

bioRxiv : the preprint server for biology·2024

Same author

Sympathetic Innervation of Interscapular Brown Adipose Tissue Is Not a Predominant Mediator of Oxytocin-Induced Brown Adipose Tissue Thermogenesis in Female High Fat Diet-Fed Rats.

Current issues in molecular biology·2024

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15

LeBris S Quinn¹, Barbara G Anderson, Lena Strait-Bodey

¹Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Tacoma,WA 98493, USA. quinnL@u.washington.edu

Experimental Gerontology

|October 27, 2009

Summary

This summary is machine-generated.

Muscle and serum Interleukin-15 (IL-15) levels decrease with age. Declines in soluble IL-15 receptor alpha (sIL-15Ralpha) expression are linked to lower IL-15, impacting body composition in aging mice.

More Related Videos

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Jun 19, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Area of Science:

Aging research
Molecular biology
Physiology

Background:

Interleukin-15 (IL-15) is a cytokine derived from skeletal muscle, known for its positive effects on muscle mass and body composition.
IL-15 modulation is a potential therapeutic strategy for sarcopenia and age-related adiposity.
Measuring physiological IL-15 levels in mice is challenging, and its translational regulation is complex.

Purpose of the Study:

To measure physiological IL-15 levels in aging mice.
To investigate age-related changes in IL-15 and its receptor alpha (IL-15Ralpha) expression in muscle and serum.
To determine the relationship between IL-15Ralpha and circulating IL-15 levels during aging.

Main Methods:

Quantification of physiological IL-15 levels in murine muscle and serum.
Analysis of IL-15 and IL-15 receptor alpha (IL-15Ralpha) mRNA and protein expression in aging mouse muscle.
Correlation analysis between serum IL-15 and muscle sIL-15Ralpha mRNA expression.

Main Results:

Muscle and serum IL-15 levels progressively decline with age in mice.
IL-15 mRNA and membrane-bound IL-15 receptor subunits in muscle do not change with age.
Soluble IL-15Ralpha (sIL-15Ralpha) mRNA expression decreases significantly with age, correlating with reduced serum IL-15.

Conclusions:

Age-associated decline in muscle sIL-15Ralpha expression contributes to decreased circulating IL-15 levels.
These findings provide a basis for studying IL-15 and sIL-15Ralpha in age-related body composition changes.
The study offers insights into the mechanisms underlying sarcopenia and adiposity in aging, using mice as a model for humans.