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Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
The quest for biomarkers in tuberculosis.
Shreemanta K Parida1, Stefan H E Kaufmann
1Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, D-10117 Berlin, Germany. parida@mpiib-berlin.mpg.de
Drug Discovery Today
|October 27, 2009
Summary
Developing new tuberculosis (TB) drugs and vaccines is slow due to the lack of reliable biomarkers. This review explores biomics platforms for TB biomarker discovery to accelerate candidate selection.
Area of Science:
- Biomedical research
- Infectious disease
- Drug discovery
Background:
- Tuberculosis (TB) drug and vaccine development has seen minimal progress in decades.
- A significant hurdle is the absence of reliable biomarkers to predict treatment efficacy and toxicity early in development.
Purpose of the Study:
- To review the current landscape of biomarker discovery for TB.
- To highlight the role of emerging biomics platforms in accelerating TB drug and vaccine development.
Main Methods:
- Literature review of biomarker discovery for TB.
- Analysis of emerging global biomics platforms (genomics, proteomics, metabolomics, etc.).
Main Results:
- Current TB biomarker discovery relies on single markers, which are insufficient.
- Biomics platforms offer powerful tools for identifying comprehensive biosignatures.
Conclusions:
- A shift from single markers to robust biosignatures is crucial for TB research.
- Implementing biosignatures will expedite the screening and selection of promising TB drug and vaccine candidates.
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