Related Experiment Video

Updated: Jun 19, 2026

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration
14:14

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

Published on: January 6, 2014

The role of neutrophils in the event of intestinal inflammation

Karen L Mumy1, Beth A McCormick

  • 1The Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.

Current Opinion in Pharmacology
|October 27, 2009
PubMed

Insights

Neutrophil migration into the gut is key for fighting infection but can damage the intestine. Understanding these mechanisms helps target therapies for noninfectious conditions.

Area of Science:

  • Gastroenterology
  • Immunology
  • Cell Biology

Background:

  • Polymorphonuclear leukocytes (PMNs), primarily neutrophils, migrate to the intestinal lumen during various diseases.
  • While crucial for pathogen clearance, excessive neutrophil activity can damage the intestinal epithelium.

Purpose of the Study:

  • To elucidate the mechanisms driving neutrophil transmigration into the intestinal lumen.
  • To identify potential therapeutic targets for inhibiting neutrophil migration in noninfectious intestinal diseases.

Main Methods:

  • This study focuses on understanding the fundamental mechanisms of neutrophil recruitment and function in the gut.
  • Further details on specific methodologies are not provided in the abstract.

Main Results:

  • Neutrophil transmigration is a complex process with implications for both host defense and intestinal homeostasis.
  • The abstract does not present specific experimental results.

Conclusions:

  • Understanding the drivers of neutrophil transmigration is essential for developing targeted treatments.
  • Inhibiting neutrophil influx during noninfectious states may prevent epithelial damage.

More Related Videos

Detecting Migration and Infiltration of Neutrophils in Mice10:33

Detecting Migration and Infiltration of Neutrophils in Mice

Published on: February 6, 2020

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...