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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Ozone and cause-specific cardiorespiratory morbidity and mortality.
Jaana I Halonen1, Timo Lanki, Pekka Tiittanen
1National Institute for Health and Welfare, Environmental Epidemiology Unit, P O Box 95, FI-70701 Kuopio, Finland.
Journal of Epidemiology and Community Health
|October 27, 2009
Summary
Ozone exposure is linked to increased asthma emergency room visits in children and hospital admissions for asthma and COPD in the elderly. Cardiovascular health effects from ozone were less evident in this study.
Area of Science:
- Environmental Health
- Epidemiology
- Public Health
Background:
- Ozone's health effects are known, but cause-specific morbidity and mortality associations are less studied.
- This study investigates short-term ozone exposure impacts on specific cardiorespiratory outcomes across different age groups.
Purpose of the Study:
- To determine short-term associations between ambient ozone levels and cause-specific cardiorespiratory mortality and morbidity.
- To analyze these associations in distinct age demographics: children, adults, and the elderly.
Main Methods:
- Utilized daily ozone measurements from Helsinki, Finland (1998-2004) during warm seasons.
- Analyzed cause-specific cardiorespiratory mortality and hospital admissions data for the elderly and adults.
- Examined ozone's association with asthma emergency room visits in children, adjusting for PM2.5 using Poisson regression.
Main Results:
- A significant positive association was observed between ozone and asthma-COPD admissions in the elderly (9.6% increase per 25 μg/m³).
- Ozone exposure showed a significant positive association with asthma emergency room visits in children (12.6% increase).
- A potential link between ozone and elderly arrhythmia admissions was suggested, slightly confounded by PM2.5.
Conclusions:
- Ambient ozone is positively associated with asthma visits in children and pooled asthma/COPD admissions in the elderly.
- The association between ozone and cardiovascular health outcomes appeared less pronounced.
- Findings highlight the specific respiratory health risks posed by short-term ozone exposure in vulnerable populations.
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