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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

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Published on: October 10, 2025

Maternal contributions to preterm delivery.

Heather A Boyd1, Gry Poulsen, Jan Wohlfahrt

  • 1Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen, Denmark. hoy@ssi.dk

American Journal of Epidemiology
|October 27, 2009
PubMed
Summary
This summary is machine-generated.

A woman's risk of preterm delivery (PTD) is significantly influenced by PTD in her female relatives, but not by her partner's history. This suggests a genetic component passed through the maternal line.

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Area of Science:

  • Obstetrics and Gynecology
  • Genetics
  • Reproductive Medicine

Background:

  • Preterm delivery (PTD) is a complex obstetric complication with known familial aggregation.
  • Specific inheritance patterns for PTD have not been clearly defined.
  • Understanding familial risk factors is crucial for PTD prevention strategies.

Purpose of the Study:

  • To investigate the influence of a woman's family history and her partner's family history on her risk of preterm delivery.
  • To identify potential inheritance patterns associated with PTD.
  • To explore the role of maternal versus paternal lineage in PTD risk.

Main Methods:

  • Utilized Danish national registers and the Danish Family Relations Database.
  • Analyzed data from 1,107,124 live singleton deliveries between 1978 and 2004.
  • Calculated risk ratios to compare PTD risk based on family histories of PTD.

Main Results:

  • Women with a history of PTD have a significantly higher risk of recurrent PTD (RR=5.6).
  • A woman's PTD risk is increased by PTD in her mother, full sisters, or maternal half-sisters (RR=1.6).
  • PTD risk was not affected by a partner's history of preterm births or PTD in paternal female relatives.

Conclusions:

  • PTD risk is strongly influenced by factors inherited through the maternal line.
  • The findings suggest potential roles for genetic imprinting or mitochondrial inheritance in PTD.
  • Further research is warranted to elucidate the specific mechanisms of female-line inheritance in PTD.