Wideband high-frequency echocardiography to evaluate myocardial infarct size
Jianping Xu1, Chengxiu Zhang, Ashwani Khanna
1Division of Cardiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA.
Objective:
This study was designed to validate the feasibility of wideband high-frequency ultrasound imaging to resolve in vivo the degree, location, and morphologic changes of myocardial infarction (MI) in a rat model.
Methods:
The left anterior descending coronary artery was ligated in the test group (n = 41), and the sham control group did not have ligation (n = 7). The rats were examined with 10- to 22-MHz echocardiography to evaluate the MI size, location, and geometric formation.
Results:
The endocardial chamber shape was deformed, with enlargement of the anteroposterior dimension and fractional shortening, and was comparable with the degree of MI both in short- and long-axis sections of the left ventricle. Histologic analysis showed remodeling to different extents corresponding to different MI sizes (small, medium, and large).
Conclusions:
The results suggest that this technique can be used in vivo to evaluate the MI location, size, and morphologic changes corresponding to the extent of the injury.
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