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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic radiosurgery for skull base meningioma
Hiroshi Igaki1, Keisuke Maruyama, Tomoyuki Koga
1Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan. ki-tky@umin.ac.jp
Neurologia Medico-Chirurgica
|October 27, 2009
Summary
Stereotactic radiosurgery effectively controls skull base meningiomas, particularly small or residual tumors. Combining microsurgery with radiosurgery offers excellent local tumor control for these challenging lesions.
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Stereotactic radiosurgery (SRS) is an emerging treatment for meningiomas.
- Skull base meningiomas pose unique treatment challenges, often affecting high-risk patients.
Purpose of the Study:
- To evaluate the clinical outcomes of SRS for skull base meningiomas.
- To identify factors influencing local tumor control after SRS.
Main Methods:
- Retrospective analysis of 98 patients with 106 skull base meningiomas treated with Leksell Gamma Knife SRS.
- Median follow-up of 53.2 months.
Main Results:
- 5-year and 10-year local tumor control rates were 86.9% and 78.9%.
- Tumor volume ≤ 4 cm³ and complete inclusion within the 14 Gy isodose line correlated with higher control rates (97.5%).
- All 25 postoperative residual tumors achieved control; cranial nerve deficits improved or remained stable in most patients.
Conclusions:
- SRS is an effective treatment for local control of skull base meningiomas.
- SRS is particularly beneficial for small or postoperative residual tumors.
- The combination of microsurgery and SRS yields excellent local control outcomes.
