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Overcoming Chronic Rejection-Can it B?

Jean Kwun1, Stuart J Knechtle

  • 1Department of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.

Transplantation
|October 27, 2009
PubMed

Despite the success of immunosuppressive drug therapy to reduce the incidence of acute rejection in organ transplantation, chronic rejection is still an impediment to long-term graft survival and tolerance. There is a growing body of evidence that B-cell production of alloantibody is an important element in the genesis of chronic rejection. Effector function of B cells in transplantation is not specifically targeted by current T-cell-directed therapeutic approaches. We briefly discuss the origin, animal models, diagnostic methods, and currently available B cell reagents that might be used in combination with existing immunosuppressive regimens to address B-cell-mediated allograft injury.

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