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Related Experiment Video

Updated: Jun 19, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Lymph node metastases in diffuse malignant peritoneal mesothelioma.

Dario Baratti¹, Shigeki Kusamura, Antonello Domenico Cabras

¹Department of Surgery, National Cancer Institute, Milan, Italy. dario.baratti@istitutotumori.mi.it

Annals of Surgical Oncology

|October 27, 2009

Summary

This summary is machine-generated.

Improved survival in diffuse malignant peritoneal mesothelioma (DMPM) patients undergoing cytoreduction and HIPEC is linked to negative lymph nodes. Careful node sampling during surgery is crucial for better outcomes in DMPM treatment.

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Published on: December 21, 2019

Area of Science:

Oncology
Surgical Oncology
Peritoneal Cancer Research

Background:

Diffuse malignant peritoneal mesothelioma (DMPM) treatment with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) shows improved survival.
The prognostic significance of lymph node involvement in DMPM remains unclear.

Purpose of the Study:

To investigate the impact of lymph node status on survival in DMPM patients treated with cytoreduction and HIPEC.
To identify clinicopathological factors influencing overall survival in DMPM.

Main Methods:

Prospective data from 83 DMPM patients undergoing cytoreduction and HIPEC were analyzed.
Pathological examination of clinically suspicious lymph nodes was performed.
Multivariate analysis assessed the impact of nodal involvement and 14 other variables on survival.

Main Results:

Overall 5-year survival was 49.5%.
Pathologically negative lymph nodes (n=27) showed significantly higher overall survival (82.5%) compared to positive nodes (n=11, 18.0%) (P=0.0024).
Pathologically negative nodes, epithelial subtype, low mitotic count, and complete cytoreduction independently correlated with increased overall survival.

Conclusions:

Pathologically negative lymph nodes are an independent predictor of increased survival in DMPM patients.
Pathological and biological features also independently correlate with improved survival.
This study highlights the importance of meticulous lymph node sampling during surgical cytoreduction for DMPM.