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Updated: Jun 19, 2026
08:56
Isolation of Murine Embryonic Hemogenic Endothelial Cells
Published on: June 17, 2016
Blood cell generation from the hemangioblast
Christophe Lancrin1, Patrycja Sroczynska, Alicia G Serrano
1Cancer Research UK, Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.
Journal of Molecular Medicine (Berlin, Germany)
|October 27, 2009
Summary
This review details blood cell generation, focusing on hematopoietic stem cells (HSCs) and their precursors. Understanding these processes aids in treating blood diseases and leukemia.
Area of Science:
- Hematology
- Developmental Biology
- Stem Cell Biology
Background:
- Blood cell generation is crucial for biological understanding and treating blood disorders.
- Hematopoietic stem cells (HSCs) are key to blood formation and have therapeutic potential.
- Transcription factors regulating blood development are often implicated in leukemia.
Purpose of the Study:
- To review the molecular and cellular mechanisms of blood development.
- To explore the role of the hemangioblast as an early hematopoietic precursor.
- To connect normal blood development to potential treatments for blood diseases and leukemia.
Main Methods:
- This is a review article, synthesizing existing research.
- Focuses on molecular and cellular mechanisms.
- Examines the role of transcription factors in hematopoiesis.
Main Results:
- Blood development originates from the hemangioblast, a precursor to both endothelial and hematopoietic cells.
- Key transcription factors are vital for early hematopoietic development.
- Understanding normal development offers insights into abnormal hematopoiesis in leukemia.
Conclusions:
- Knowledge of blood cell generation can inform new therapies for blood diseases.
- Further understanding of HSCs could lead to improved regenerative medicine approaches.
- Insights into developmental pathways are critical for leukemia research.
Related Concept Videos
01:21Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
01:34Production of Formed Elements
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
01:20Overview of Hematopoiesis
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
01:19Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
01:07Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
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01:01Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...