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Related Experiment Video

Updated: Jun 19, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Primary peritoneal malignant mixed mesodermal (Müllerian) tumor.

Mahmoud R Hussein¹, Saad Rezk Abudlwahed Hussein, Ahmad Rezk Abd-Elwahed

¹Department of Pathology, Assir Central (Abha, KSA) and Assuit University Hospitals, Assuit University, Assuit, Egypt. mrcpath17@gmail.com

|October 28, 2009

Summary

This summary is machine-generated.

Malignant mixed mesodermal tumors (MMMT) are rare, aggressive cancers. This case highlights primary peritoneal MMMT, a highly malignant neoplasm with poor prognosis and poorly understood origins.

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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

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Published on: April 21, 2022

Area of Science:

Oncology
Pathology
Gynecologic Oncology

Background:

Malignant mixed mesodermal tumor (MMMT) is a rare biphasic neoplasm comprising epithelial and mesenchymal elements.
Extragenital MMMTs, including primary peritoneal MMMT, are exceptionally rare and thought to originate from the secondary Müllerian system.

Observation:

A case of primary peritoneal MMMT in a 65-year-old woman presenting with abdominal fullness and pain.
Histological examination revealed a biphasic tumor with carcinomatous and sarcomatous (rhabdomyosarcoma) components.
Immunohistochemistry confirmed epithelial (cytokeratin, EMA) and mesenchymal (vimentin, S-100, desmin) markers.

Findings:

Primary peritoneal MMMT is a highly malignant neoplasm.
The tumor demonstrated aggressive behavior with a poor prognosis.
The patient refused treatment and died within three months.

Implications:

Further research is needed to understand the precise origin, histogenesis, and molecular alterations of primary peritoneal MMMT.
Early diagnosis and understanding of this rare entity are crucial for improving patient outcomes.
This case underscores the aggressive nature and diagnostic challenges associated with extragenital MMMTs.