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Acinic cell carcinoma. Clinicopathologic review
J E Lewis1, K D Olsen, L H Weiland
1Section of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.
Cancer
|January 1, 1991
Summary
Acinic cell carcinoma can recur locally up to 30 years after initial treatment. Pain, invasion, and specific microscopic features indicate a poorer prognosis for patients with this salivary gland cancer.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Acinic cell carcinoma (ACC) is a rare malignant salivary gland neoplasm.
- Long-term follow-up data and prognostic factors for ACC are not well-established.
Purpose of the Study:
- To assess long-term outcomes in patients with acinic cell carcinoma.
- To identify clinicopathologic features predictive of disease progression and recurrence.
Main Methods:
- Retrospective review of 90 acinic cell carcinoma cases treated at the Mayo Clinic.
- Analysis of patient data including treatment, histology, morphology, and long-term follow-up (≥10 years or until death).
Main Results:
- 44% of primary treatment cases experienced local recurrence, 19% developed metastasis, and 25% died of disease.
- Recurrence was observed as late as 30 years post-presentation, with disease-related death occurring up to 38 years.
- Poor prognostic indicators included pain, fixation, gross invasion, desmoplasia, atypia, increased mitotic activity, and initial excision.
Conclusions:
- Acinic cell carcinoma requires long-term surveillance due to the potential for late recurrences.
- Specific clinical and histopathologic features are associated with adverse outcomes, guiding prognostic assessment.