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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Future developments in osteoporosis therapy.

K W Ng1

  • 1Department of Endocrinology & Diabetes, The University of Melbourne, St Vincent's Hospital, Fitzroy, Victoria 3065, Australia. kongwn@unimelb.edu.au

Endocrine, Metabolic & Immune Disorders Drug Targets
|October 28, 2009
PubMed
Summary
This summary is machine-generated.

New osteoporosis therapies target bone cell pathways to improve bone formation and resorption. Future treatments may include novel anti-resorptives and anabolic agents, offering promising advancements in osteoporosis management.

Related Experiment Videos

Last Updated: Jun 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

  • Bone biology and metabolic pathways
  • Pharmacological interventions for osteoporosis

Background:

  • Current osteoporosis treatments focus on anti-resorptives (inhibiting osteoclasts) or parathyroid hormone (stimulating osteoblasts).
  • Advances in bone cell biology reveal new molecular targets for modulating bone metabolism.

Purpose of the Study:

  • To explore next-generation osteoporosis therapies targeting specific molecular pathways.
  • To review novel agents that may inhibit bone resorption or stimulate bone formation.

Main Methods:

  • Review of potential therapeutic molecules targeting integrin, Src tyrosine kinase, vacuolar H+-ATPase, chloride channels, cathepsin K, Wnt signaling, and selective androgen receptor modulators.
  • Examination of preclinical and early investigational data for novel osteoporosis treatments.

Main Results:

  • Next-generation therapies may include novel anti-resorptives that inhibit osteoclast function without affecting bone formation.
  • Anabolic strategies targeting the Wnt signaling pathway and selective androgen receptor modulators show potential for increasing bone formation.

Conclusions:

  • Emerging osteoporosis therapies targeting specific cellular pathways hold promise for effective treatment and prevention.
  • Future treatments must prioritize safety, efficacy, affordability, and specificity of action.