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Directing Proteins to the Rough Endoplasmic Reticulum01:34

Directing Proteins to the Rough Endoplasmic Reticulum

The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Protein Families02:47

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
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Conservation of Protein Domains Over Different Proteins

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Related Experiment Video

Updated: Jun 19, 2026

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
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Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability

Published on: April 2, 2015

The SR protein family.

Peter J Shepard1, Klemens J Hertel

  • 1Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697-4025, USA.

Genome Biology
|October 28, 2009
PubMed
Summary

Serine/arginine-rich (SR) proteins are essential for gene expression, regulating pre-mRNA processing, splicing, and mRNA metabolism. These proteins play diverse roles from splicing to nuclear export, highlighting their critical function in gene regulation.

Area of Science:

  • Molecular Biology
  • Gene Expression Regulation
  • RNA Metabolism

Background:

  • Pre-mRNA processing is vital for metazoan gene expression.
  • Serine/arginine-rich (SR) proteins are key players in these essential processing events.
  • SR proteins ensure efficient gene expression.

Purpose of the Study:

  • To elucidate the diverse functional roles of SR proteins in gene expression.
  • To highlight the importance of SR proteins in mRNA metabolism.
  • To detail the structural characteristics of SR proteins.

Main Methods:

  • Characterization of SR protein structure, including RNA recognition motifs (RRMs) and RS domains.
  • Analysis of SR protein interactions with RNA and other protein components.

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Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

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Related Experiment Videos

Last Updated: Jun 19, 2026

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
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  • Review of functional roles in constitutive and alternative pre-mRNA splicing.

    • Main Results:

    • SR proteins possess distinct structural domains (RRM and RS domain) for RNA and protein interactions.
    • SR proteins are involved in a wide spectrum of gene expression activities.
    • Their functions extend beyond splicing to include mRNA nuclear export, nonsense-mediated decay, and translation.

    Conclusions:

    • SR proteins are indispensable for efficient gene expression and mRNA metabolism.
    • Their diverse functions underscore their critical regulatory role in gene expression.
    • Understanding SR proteins is crucial for comprehending mRNA processing and regulation.