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Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
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Published on: March 18, 2020

A brief focus on memory cells in transplantation

A Le Moine1, B Vokaer, L M Charbonnier

  • 1Medical Institute for Immunology, Université Libre de Bruxelles, 8 rue A Bolland, 6041 Gosselies, Belgium. alemoine@ulb.ac.be

Transplantation Proceedings
|October 28, 2009
PubMed

T and B memory cells are critical for host defences against pathogens. However, converging lines of evidence indicate that alloreactive memory T cells can play a detrimental role in the transplantation setting. This emergence of memory cells seems to be facilitated by several induction therapies and immunosuppressive agents, which lead to T cell loss. Herein, we briefly review some clinical and experimental observations from the literature, highlighting the immunological risk associated with enhanced T-cell memory responses.

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