Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 19, 2026

Photochemical Oxidative Growth of Iridium Oxide Nanoparticles on CdSe@CdS Nanorods
05:41

Photochemical Oxidative Growth of Iridium Oxide Nanoparticles on CdSe@CdS Nanorods

Published on: February 11, 2016

Neuronal cell growth on iridium oxide.

Katrin Göbbels1, Thomas Kuenzel, André van Ooyen

  • 1Institute of Biology II, Unit of Developmental Biology and Morphology of Animals, RWTH Aachen University, Mies-van-der-Rohe-Str.15, D-52074 Aachen, Germany. goebbels@bio2.rwth-aachen.de

Biomaterials
|October 28, 2009
PubMed
Summary

Iridium oxide shows promise for neural recording and stimulation devices. Coatings improve neuron adhesion, but increased surface roughness does not enhance neurocompatibility for multi electrode arrays (MEAs).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Patients With Relapsing Multiple Sclerosis Switching to Ocrelizumab Due to Suboptimal Treatment Response: Results of the 4-Year CASTING-LIBERTO Trial.

European journal of neurology·2026
Same author

Polymer Replicas of Fs-Laser-Induced Periodic Surface Structures for Cell Attachment.

Materials (Basel, Switzerland)·2026
Same author

Electrosensitivity in planthoppers (Insecta: Hemiptera: Auchenorrhyncha: Fulgoromorpha).

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

Targeting IL-6 Receptor Signaling with Satralizumab in Thyroid Eye Disease: Design of the Phase 3 SatraGO-1 and SatraGO-2 Trials.

Ophthalmology and therapy·2025
Same author

Ocrelizumab in Early-Stage Relapsing-Remitting Multiple Sclerosis: The Phase IIIb ENSEMBLE 4-Year, Single-Arm, Open-Label Trial.

Neurology·2024
Same author

Oriented artificial nanofibers and laser induced periodic surface structures as substrates for Schwann cells alignment.

Open research Europe·2024

Area of Science:

  • Materials Science
  • Neuroscience
  • Biocompatibility

Background:

  • Iridium oxide is a promising material for multi electrode array (MEA) systems used in neural stimulation and recording.
  • Investigating the biocompatibility of iridium and its oxides is crucial for developing advanced neural interfaces.

Purpose of the Study:

  • To evaluate the biocompatibility of pure iridium and various iridium oxide surfaces with different roughness.
  • To assess the impact of surface coatings (Concanavalin A, poly-(D)-lysine) on neuron adhesion and growth.
  • To determine the optimal surface morphology of iridium oxide for neurocompatibility in MEA applications.

Main Methods:

  • Biocompatibility testing using insect (locust) and vertebrate (chicken) neurons.
  • Surface characterization including R(a) value determination, contact angle measurement, and marker enzyme assay.

More Related Videos

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
09:31

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Published on: April 27, 2015

Related Experiment Videos

Last Updated: Jun 19, 2026

Photochemical Oxidative Growth of Iridium Oxide Nanoparticles on CdSe@CdS Nanorods
05:41

Photochemical Oxidative Growth of Iridium Oxide Nanoparticles on CdSe@CdS Nanorods

Published on: February 11, 2016

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
09:31

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Published on: April 27, 2015

  • Evaluation of neuron adhesion and growth on coated and non-modified iridium oxide substrates.

    • Main Results:

    • All tested iridium oxide substrates supported locust neuron growth.
    • Chicken neuron adhesion was significantly improved on coated iridium oxide surfaces.
    • Increased surface roughness of iridium oxide films did not enhance neurocompatibility.
    • Successful coating of iridium oxide films with Concanavalin A and poly-(D)-lysine was confirmed.

    Conclusions:

    • Iridium oxide films are suitable for MEA development, with specific surface coatings enhancing neuron adhesion.
    • Surface roughness is not a critical factor for improving neurocompatibility in these iridium oxide systems.
    • Future MEA designs can utilize iridium oxide surface morphologies optimized for stimulation, as neurocompatibility is not compromised.