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Distribution of HDL-cholesterol and non-HDL-cholesterol in Brazilian children and adolescents--the Floripa study

I Giuliano1, S Freitas, M Coutinho

  • 1Universidade Federal de Santa Catarina, Departamento de Pediatria, Trindade, Florianópolis, SC, Brazil. isabela@ccs.ufsc.br

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|October 28, 2009
PubMed

Insights

Low HDL-cholesterol (HDL-C) levels in Brazilian children were linked to inflammation and obesity indicators. High non-HDL-cholesterol (nHDL-C) was associated with abdominal obesity, darker skin color, and higher income.

Area of Science:

  • Pediatric Cardiology
  • Lipid Metabolism
  • Public Health

Background:

  • High-density lipoprotein cholesterol (HDL-C) and non-HDL-cholesterol (nHDL-C) play roles in atherosclerosis.
  • Understanding their distribution in pediatric populations is crucial for early cardiovascular risk assessment.

Purpose of the Study:

  • To determine the distribution of HDL-C and nHDL-C in a Brazilian pediatric sample.
  • To investigate associations between HDL-C and nHDL-C levels and cardiovascular and socio-cultural variables.

Main Methods:

  • Random selection of children and adolescents from Florianopolis.
  • Administration of questionnaires, physical examinations, and blood sample collection.
  • Enzymatic and Direct methods for cholesterol level determination; logistic regression for association analysis.

Main Results:

  • 23% of participants had low HDL-C, and 25% had high nHDL-C.
  • Low HDL-C associated with high C-reactive protein, paternal tobacco use, and high triceps-to-subscapular index.
  • High nHDL-C associated with high waist circumference, black skin color, and high income.

Conclusions:

  • Low HDL-C levels in this pediatric sample were linked to clinical factors like C-reactive protein and a centripetal fat pattern.
  • High nHDL-C levels were associated with abdominal obesity, skin color, and economic class.
Abstract

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