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Related Concept Videos

Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

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Related Experiment Video

Updated: Jun 19, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

PDBe: Protein Data Bank in Europe.

S Velankar1, C Best, B Beuth

  • 1Protein Databank in Europe, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. sameer@ebi.ac.uk

Nucleic Acids Research
|October 28, 2009
PubMed
Summary
This summary is machine-generated.

The Protein Data Bank in Europe (PDBe) enhances the global Protein Data Bank (PDB) archive with improved data quality and new services. Users can now explore protein structures and interactions through advanced querying and user-friendly interfaces.

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Related Experiment Videos

Last Updated: Jun 19, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Published on: July 16, 2017

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

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09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Data Archiving

Background:

  • The Protein Data Bank (PDB) is a crucial archive for bio-macromolecular structure data.
  • Enhancing data quality and consistency is vital for structural biology research.
  • The Protein Data Bank in Europe (PDBe) collaborates globally to maintain and improve the PDB.

Purpose of the Study:

  • To enhance the quality and consistency of the international PDB archive.
  • To develop new services for accessing and querying structural data.
  • To integrate curated derived data with existing structural information.

Main Methods:

  • Developed a new database infrastructure using remediated PDB archive data.
  • Created a specialized database for protein-ligand interactions.
  • Implemented new services for textual and 3D structure-based queries.
  • Designed user-friendly 'PDBeView Atlas pages' for PDB entry overviews.

Main Results:

  • Improved quality and consistency of the PDB archive.
  • New database infrastructure supporting enhanced data management.
  • Advanced querying capabilities for users.
  • User-friendly interfaces for data exploration.
  • Enhanced tools for structure deposition and analysis through community involvement.

Conclusions:

  • PDBe has successfully upgraded its infrastructure and services for the PDB.
  • New tools facilitate easier access and analysis of bio-macromolecular structures.
  • Collaboration with scientific communities drives continuous improvement in structural data archiving.