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Validation of a case definition to define hypertension using administrative data
Hude Quan1, Nadia Khan, Brenda R Hemmelgarn
1Department of Community Health Sciences, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada. hquan@ucalgary.ca
Insights
Administrative data accurately identifies hypertension cases using a definition of "2 claims within 2 years or 1 hospitalization." This method is reliable for public health surveillance and research, showing high validity across different regions and time periods.
Area of Science:
- Health Informatics
- Epidemiology
- Public Health Surveillance
Background:
- Accurate case definitions are crucial for hypertension surveillance and research.
- Administrative data offers a potentially vast and cost-effective data source.
- Validation of administrative data definitions against physician charts is necessary.
Purpose of the Study:
- To validate the accuracy of hypertension case definitions derived from administrative data.
- To compare the validity of different case definitions across time and geographic regions.
- To assess the utility of administrative data for hypertension case identification.
Main Methods:
- Physician charts were randomly selected from urban and rural family physician clinics in Alberta and British Columbia, Canada (2001-2004).
- Charts were linked to administrative data using unique personal health numbers.
- Validity indices (sensitivity, specificity, PPV, NPV, kappa) were calculated for 8 case definitions using physician diagnoses as the gold standard.
Main Results:
- The prevalence of hypertension ranged from 18.8% to 33.3% based on the year and region.
- The definition '2 claims within 2 years or 1 hospitalization' demonstrated the highest validity (sensitivity 75%, specificity 94%, PPV 81%, NPV 92%, kappa 0.71).
- Sensitivities were consistent across regions, years, and provinces after adjustments, though positive predictive value showed slight regional variation.
Conclusions:
- Administrative data, particularly the '2 claims within 2 years or 1 hospitalization' definition, is a relatively valid source for identifying hypertension cases.
- This validated definition supports the use of administrative data for large-scale hypertension surveillance and research.
- Findings suggest administrative data can reliably define hypertension cases for public health initiatives.
Abstract:
We validated the accuracy of case definitions for hypertension derived from administrative data across time periods (year 2001 versus 2004) and geographic regions using physician charts. Physician charts were randomly selected in rural and urban areas from Alberta and British Columbia, Canada, during years 2001 and 2004. Physician charts were linked with administrative data through unique personal health number. We reviewed charts of approximately 50 randomly selected patients >35 years of age from each clinic within 48 urban and 16 rural family physician clinics to identify physician diagnoses of hypertension during the years 2001 and 2004. The validity indices were estimated for diagnosed hypertension using 3 years of administrative data for the 8 case-definition combinations. Of the 3,362 patient charts reviewed, the prevalence of hypertension ranged from 18.8% to 33.3%, depending on the year and region studied. The administrative data hypertension definition of "2 claims within 2 years or 1 hospitalization" had the highest validity relative to the other definitions evaluated (sensitivity 75%, specificity 94%, positive predictive value 81%, negative predictive value 92%, and kappa 0.71). After adjustment for age, sex, and comorbid conditions, the sensitivities between regions, years, and provinces were not significantly different, but the positive predictive value varied slightly across geographic regions. These results provide evidence that administrative data can be used as a relatively valid source of data to define cases of hypertension for surveillance and research purposes.
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