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Node Analysis for AC Circuits01:14

Node Analysis for AC Circuits

Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...

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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

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Published on: October 1, 2007

Tape underlayment rotary-node (TURN) valves for simple on-chip microfluidic flow control.

Dmitry A Markov1, Steven Manuel, Leslie M Shor

  • 1Department of Biomedical Engineering, Vanderbilt University, VU Station B 351631, Nashville, TN 37235, USA. d.markov@vanderbilt.edu

Biomedical Microdevices
|October 28, 2009
PubMed
Summary

We developed a simple method to create multiple manual microfluidic control valves in polydimethylsiloxane (PDMS) devices. These Tape Underlayment Rotary-Node (TURN) valves offer on/off and graded fluid control, enhancing microfluidic system applications.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Materials Science

Background:

  • Microfluidic devices require precise fluid control.
  • Existing valve systems can be complex to fabricate and integrate.
  • Manual control is often desired for flexibility in microfluidic experiments.

Purpose of the Study:

  • To present a simple, reliable fabrication method for manual microfluidic control valves.
  • To introduce the Tape Underlayment Rotary-Node (TURN) valve system.
  • To demonstrate the versatility and applications of TURN valves in microfluidics.

Main Methods:

  • Fabrication involves a hot-glue gun and a machined brass mold for creating a valve tape.
  • The valve tape is integrated onto a partially cured PDMS microfluidic device.
  • An over-layer of PDMS is used to permanently affix the valve tape, creating an enclosed underlayment.

Main Results:

  • Successfully produced multiple, manually activated screwdriver-actuated valves on PDMS microfluidic chips.
  • TURN valves provide both on/off and graded control of fluid flow.
  • Demonstrated control of microfluidic flow, molecular diffusion onset, and channel connectivity.

Conclusions:

  • The TURN valve fabrication method is simple, reliable, and suitable for soft lithography labs.
  • TURN valves offer advantages such as parallel fabrication, low installation risk, high torque, and customization.
  • TURN valves are practical for applications in chemotaxis assays, bioreactors, and microbial interaction studies.