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Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...

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Updated: Jun 19, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

[Pre-, peri- and postpartal depression].

U Reulbach1, S Bleich, J Knörr

  • 1Psychiatrische und Psychotherapeutische Klinik, Universitätsklinik Erlangen.

Fortschritte Der Neurologie-Psychiatrie
|October 28, 2009
PubMed
Summary
This summary is machine-generated.

Postpartum depression is common, with higher depression scores noted during pregnancy. Early detection in pregnant women is crucial for effective prevention strategies and improved maternal health outcomes.

More Related Videos

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

Related Experiment Videos

Last Updated: Jun 19, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Mental Health
  • Psychiatry

Context:

  • Postpartal affective disorders affect 8-15% of mothers.
  • Untreated depression can lead to chronic depression, social withdrawal, and child behavioral issues.
  • Early detection of at-risk pregnant women is crucial.

Purpose:

  • To assess the prevalence and predictive value of prenatal and postpartum depression symptoms.
  • To identify women at risk for postpartal affective disorders.
  • To evaluate the effectiveness of early detection and intervention strategies.

Summary:

  • A prospective study (FRAMES) followed 1,100 pregnant women, with a substudy (Blue FRAMES) of 554 women.
  • The Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HAMD) were used at prepartal, 3-day postpartum, and 6-month postpartum intervals.
  • Higher EPDS scores were observed prepartum, decreasing shortly postpartum before rising again, though remaining lower than prepartum levels by six months.

Impact:

  • Prenatal depression scores show good predictive value for postpartum affective disorders.
  • There is a significant need and opportunity for improved prevention of postpartum disorders.
  • Targeting interventions during the prepartum period can enhance maternal and child well-being.