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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

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Related Experiment Video

Updated: Jun 19, 2026

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
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Published on: August 9, 2024

Non-invasive fetal lung assessment using diffusion-weighted imaging.

W Lee1, A Krisko, A Shetty

  • 1Division of Fetal Imaging, Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, MI, USA. wlee@beaumont.edu

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|October 28, 2009
PubMed
Summary
This summary is machine-generated.

Diffusion-weighted imaging (DWI) provides reproducible apparent diffusion coefficients (ADCs) for fetal lung tissue. These ADC measurements are independent of fetal age and lung volume, offering a reliable biomarker.

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Area of Science:

  • Medical Imaging
  • Fetal Development
  • Diffusion MRI

Background:

  • Accurate assessment of fetal lung development is crucial.
  • Diffusion-weighted imaging (DWI) offers a non-invasive method to study tissue microstructural changes.

Purpose of the Study:

  • To establish a reproducible DWI method for estimating water diffusion in human fetal lungs.
  • To investigate the relationship between apparent diffusion coefficients (ADCs), fetal age, and lung volume.

Main Methods:

  • Utilized a 1.5-Tesla MRI system with single-shot DWI sequences.
  • Acquired data from normal pregnant volunteers, calculating ADCs using b-values of 0 and 1000.
  • Assessed reproducibility using Bland-Altman analysis for inter- and intra-examiner variability.

Main Results:

  • Developed a reproducible method for fetal lung ADC estimation with low coefficient of variation (5.6%).
  • ADC values showed no significant correlation with menstrual age (P=0.70) or total lung volume (P=0.94).
  • Demonstrated good inter- and intra-examiner agreement for ADC measurements.

Conclusions:

  • Apparent diffusion coefficients (ADCs) in the fetal lung are reproducible using DWI.
  • ADC measurements are independent of gestational age and lung volume, suggesting stability during development.
  • This DWI method provides a reliable tool for fetal lung research.