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[Humanized model for acute myeloid leukemia]

Fumihiko Ishikawa1

  • 1Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 29, 2009
PubMed

To investigate human hematopoiesis and immunity in vivo, we have been making efforts to reconstitute these systems in mice by intravenously injecting purified human stem cells into NOD/SCID/IL2rgKO newborns. This xenogeneic transplantation system supports long-term engraftment, multi-lineage differentiation, and self-renewal capacity of human cord blood-derived hematopoietic stem cells (HSCs). We here introduce our recent application of the NOD/SCID/IL2rgKO newborn xenotransplant system to create in vivo models for human hematological malignancies and to understand pathophysiology of human AML.

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