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Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model
Published on: December 18, 2012
Immunotherapy of human cancers using gene modified T lymphocytes
Juan F Vera1, Malcolm K Brenner, Gianpietro Dotti
1Center for Cell and Gene Therapy, Department of Medicine, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, 6621 Fannin Avenue, Houston, TX 77030, USA.
None:
Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.
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