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Related Experiment Video

Updated: Jun 19, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Developing novel therapeutic approaches to frailty.

John E Morley¹

¹Division of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St. Louis, Missouri 63104, USA. morley@slu.edu

Current Pharmaceutical Design

|October 29, 2009

Summary

Frailty is a recognized clinical condition treatable with medications. Future drug development aims to address frailty syndrome components, complementing current exercise therapies.

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Area of Science:

Gerontology
Pharmacology
Clinical Medicine

Background:

Frailty is increasingly recognized as a distinct clinical entity.
The condition is potentially amenable to pharmacological interventions.

Purpose of the Study:

To review current and emerging drug therapies for frailty.
To discuss the future landscape of pharmacotherapy for frailty syndrome.

Main Methods:

Literature review of available and investigational drugs for frailty.
Analysis of therapeutic targets for frailty syndrome components.

Main Results:

Currently, exercise is the primary intervention for frailty.
Several drug classes are under investigation for frailty treatment.
Numerous medications are anticipated to be available within the next decade.

Conclusions:

Pharmacological treatments for frailty are expected to expand significantly.
Drug therapies will likely complement existing exercise-based interventions for frailty syndrome.