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Updated: Jun 19, 2026

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

Prophylaxis of erectile function after radical prostatectomy with phosphodiesterase type 5 inhibitors

F Deho1, A Gallina, A Salonia

  • 1Department of Urology, Vita-Salute University, Milan, Italy.

Current Pharmaceutical Design
|October 29, 2009
PubMed

Insights

Phosphodiesterase type 5 inhibitors may help prevent erectile dysfunction (ED) after radical prostatectomy (RP). Early use of these drugs can improve recovery of erectile function post-surgery.

Area of Science:

  • Urology
  • Oncology
  • Pharmacology

Background:

  • Erectile dysfunction (ED) is a common complication following radical prostatectomy (RP) for prostate cancer.
  • Current treatments for post-RP sexual dysfunction are varied.
  • Basic science suggests phosphodiesterase type 5 (PDE5) inhibitors may protect against surgical damage.

Purpose of the Study:

  • To analyze factors influencing erectile function after RP.
  • To evaluate the evidence for pharmacological prophylaxis and treatment of ED post-RP.

Main Methods:

  • Review of scientific literature on ED after RP.
  • Analysis of studies on PDE5 inhibitors for ED prevention and treatment.

Main Results:

  • Pharmacological prophylaxis with PDE5 inhibitors soon after RP may improve erectile function recovery rates.
  • On-demand PDE5 inhibitor treatment is effective for ED in patients post-RP.
  • PDE5 inhibitors show potential in preventing endothelial damage from ischemia-reperfusion and denervation.

Conclusions:

  • Pharmacological prophylaxis with PDE5 inhibitors is a promising strategy for preserving erectile function after RP.
  • Further research may expand the role of PDE5 inhibitors in post-prostatectomy sexual health management.

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