Related Experiment Video

Updated: Jun 19, 2026

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

Is there a need for more than one left ventricular lead in some patients?

Islem Sanaa1, Frédéric Franceschi, Sébastien Prévôt

  • 1Cardiology Department, University Hospital La Timone, Cardiologie 9ème étage, 264 Rue Saint Pierre, 13385 Marseille Cédex 5, France.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|October 29, 2009
PubMed

Insights

Dual-site left ventricular pacing may improve cardiac resynchronization therapy (CRT) outcomes in heart failure patients. Further research is needed to confirm if this dual-site approach offers a significant benefit over conventional single-site CRT.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) improves heart failure outcomes in select patients.
  • Conventional CRT achieves significant left ventricular (LV) reverse remodeling in only 60-70% of patients.
  • Incomplete resynchronization may explain the limited efficacy of standard CRT.

Purpose of the Study:

  • To investigate the potential benefits of dual-site LV CRT compared to single-site LV CRT.
  • To explore if dual-site LV pacing leads to more physiological and faster LV activation.
  • To evaluate the efficacy of dual-site LV pacing in patients with chronic heart failure.

Main Methods:

  • A randomized study, the Triple-Site Cardiac Resynchronization study of Patients with Heart Failure (TRUST CRT), is ongoing.
  • The study compares single-site versus dual-site LV pacing strategies.
  • Patient outcomes related to CRT effectiveness are being assessed.

Main Results:

  • The TRUST CRT study is currently ongoing, and results are not yet available.
  • Theoretical advantages of dual-site LV CRT include faster and more physiological LV activation.
  • Some clinical evidence suggests potential benefits of dual LV pacing.

Conclusions:

  • A definitive benefit of dual-site LV pacing in chronically implanted patients remains unproven.
  • Further evidence from ongoing studies like TRUST CRT is required to establish the superiority of dual-site LV CRT.
  • Optimizing LV activation through advanced pacing strategies may enhance CRT effectiveness.

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