Related Experiment Video
Updated: Jun 19, 2026
04:05
A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Ulcerative colitis: Al-Gassim experience
Qais Qutub Contractor1, Tasneern Qais Contractor, Imran Ul Haque
1Department of Medicine, King Fahad Specialist Hospital, Buraidah, Al-Gassim, Saudi Arabia.
Summary
Ulcerative colitis (UC) in Saudi Arabia often presents with severe clinical and histological manifestations, particularly in males. Most patients responded well to salazopyrine, with surgery reserved for malignancy.
Area of Science:
- Gastroenterology
- Internal Medicine
- Colorectal Surgery
Background:
- Increasing incidence of ulcerative colitis (UC) reported in Arab populations.
- Limited data on clinical severity, endoscopic, and histological grading of UC in this demographic.
- Need for localized data to inform patient care and management strategies.
Purpose of the Study:
- To evaluate the disease severity and treatment response in ulcerative colitis patients.
- To assess clinical, endoscopic, and histological parameters in a Saudi Arabian cohort.
- To identify complications and outcomes in patients managed at a tertiary care center.
Main Methods:
- Retrospective analysis of 34 ulcerative colitis patient records (1990-2002).
- Inclusion of clinical severity, endoscopic grading, histological assessment, and treatment response.
- Evaluation of complication frequency and surgical intervention necessity.
Main Results:
- The study included 21 males and 13 females with a median age of 35 years.
- 47% of patients presented with severe clinical disease, 29% with endoscopic grade 4, and 68% with severe histological UC.
- Salazopyrine was the primary treatment for 85% of patients, with proctocolectomy performed in two cases due to malignancy.
Conclusions:
- Ulcerative colitis in the studied population exhibits variable severity, with a higher prevalence in males.
- Salazopyrine demonstrated effectiveness in managing most ulcerative colitis cases.
- Surgical intervention was primarily indicated for the detection of malignancy.
Related Concept Videos
01:29Drugs for Treatment of Ulcerative Colitis in IBD
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
01:26Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...