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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human papillomavirus infection in Beijing, People's Republic of China: a population-based study
1Beijing Obstetric and Gynecology Hospital, Capital Medical University, No. 251 Yao Jiayuan Road, Chaoyang District, Beijing 100026, China.
Background:
No recent data exist on human papillomavirus (HPV) infection in Beijing, People's Republic of China.
Materials And Method:
We interviewed and examined a representative, randomly selected sample of 5552 sexually active women aged 25-54 years. Cervical cell samples were analysed for HPV DNA by a MY09/11-based PCR assay.
Results:
Human papillomavirus prevalence was 6.7% overall and 4.8% among women without cervical abnormalities. Of the 21 subtypes identified, HPV16 was the commonest type (2.6% overall; 39.1% of HPV-positive women), followed by HPV 58 (1.0%), 33 (0.8%), 43 (0.7%) and 56 (0.7%). High-risk HPV types predominated in all age groups. Human papillomavirus prevalence was highest in young to middle-aged women. Marital status, number of husband's sexual partners, age at sexual debut and nulligravidity were all associated with being HPV positive.
Conclusions:
In our survey, HPV 16, HPV 58 and HPV 33 were the most prevalent HPV types in Beijing, indicating the potential for the prophylactic HPV 16/18 vaccine in China.
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