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Updated: Jun 19, 2026
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Chinese women's preferences for prenatal diagnostic procedure and their willingness to trade between procedures
Yiu Man Chan1, Daljit Singh Sahota, Tak Yeung Leung
1Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Objective:
To assess Chinese women's preference for the choice of a prenatal diagnosis test, karyotyping or rapid aneuploidy, and its relationship to maternal psychological state.
Study Design:
Three hundred consenting women completed a self administered structured questionnaire which documented their psychological state and their preferred choice of diagnostic test for chromosomal abnormality using a discrete choice experiment design. Diagnostic tests were categorised according to three attributes: completeness of chromosomal information, procedure-to-result time interval and cost.
Results:
Participants indicated a preference towards the karyotype test irrespective of cost and procedure-to-result time interval. The value of obtaining the extra information provided by karyotyping above that of rapid aneuploidy was pound267.82 (95% CI 226.71-323.31). Women would only accept the rapid aneuploidy test if results where available 18 days sooner than if they were undergoing a karyotyping test. Among women who traded between diagnostic tests, the value of extra chromosomal information was reduced to pound153.83 (95% CI 125.81-192.19). Women with high trait anxiety scores (>40) did not preferentially select one test.
Conclusion:
Chinese women showed a strong preference towards performing a full karyotype test and having a full chromosomal assessment performed for their pregnancy.
