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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jun 19, 2026

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
08:33

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

Published on: December 15, 2014

Neutrophils and asthma.

J Monteseirín1

  • 1Immunology and Allergy Service, University Hospital Virgen Macarena, Sevilla, Spain. fmonteseirinm@meditex.es

Journal of Investigational Allergology & Clinical Immunology
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Neutrophils play a key role in asthma, acting as the first responders to allergic reactions. Their presence is linked to severe asthma and sudden attacks, and they are cleared by apoptosis during response resolution.

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Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics
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Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
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Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples

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Related Experiment Videos

Last Updated: Jun 19, 2026

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
08:33

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

Published on: December 15, 2014

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics
07:37

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics

Published on: June 7, 2018

Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
09:23

Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples

Published on: May 21, 2021

Area of Science:

  • Immunology
  • Pulmonology
  • Allergy

Background:

  • Eosinophilic airway inflammation is a known feature of chronic, stable asthma.
  • Emerging evidence highlights the significant role of neutrophils in asthma pathogenesis.
  • Neutrophils are early cellular responders at allergic reaction sites.

Purpose of the Study:

  • To elucidate the role of neutrophils in asthma.
  • To understand the clinical implications of neutrophil presence in asthma.
  • To investigate the mechanism of neutrophil clearance in allergic airway responses.

Main Methods:

  • Review of existing literature on asthma pathophysiology.
  • Analysis of cellular recruitment and function in allergic airway inflammation.
  • Examination of neutrophil apoptosis in the context of allergic responses.

Main Results:

  • Neutrophil infiltration occurs early in the allergic reaction cascade.
  • Neutrophil presence correlates with specific clinical presentations in asthma.
  • Neutrophil presence is associated with severe chronic asthma and acute exacerbations.
  • Neutrophil apoptosis is a critical mechanism for resolving the allergic response.

Conclusions:

  • Neutrophils are integral to asthma development and severity.
  • Understanding neutrophil involvement is crucial for managing severe asthma and sudden attacks.
  • Targeting neutrophil apoptosis may offer therapeutic strategies for asthma resolution.