Related Experiment Video
Updated: Jun 19, 2026

09:08
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Total synthesis of the putative structure of lucentamycin A
Ujjwal Pal1, Sujeewa Ranatunga, Yamuna Ariyarathna
1Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Organic Letters
|October 30, 2009
Abstract:
A rapid and stereoselective enolate-Claisen rearrangement provides access to the 4-ethylidene-3-methylproline (Emp) subunit of lucentamycin A. Synthesis of the putative structure of the cytotoxic natural product suggests the need for structural revision.

