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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Vaccinations01:51

Vaccinations

Overview
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: Jun 19, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Update on vaccination guidelines for allergic children.

John M Kelso1

  • 1Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, CA, USA. kelso.john@scrippshealth.org

Expert Review of Vaccines
|October 30, 2009
PubMed
Summary

Children with allergies can safely receive immunizations, but require special precautions for potential vaccine component allergies. Allergy evaluations are recommended after adverse reactions to guide future vaccinations.

Area of Science:

  • Pediatrics
  • Allergology
  • Immunology

Background:

  • Children with allergic or atopic diseases need immunization.
  • Vaccination in these children requires specific considerations and precautions.
  • Potential allergies to vaccine components like gelatin or egg exist.

Purpose of the Study:

  • To outline considerations for vaccinating children with allergic diseases.
  • To address concerns regarding vaccine safety in atopic children.
  • To clarify the relationship between vaccination and allergic disease development.

Main Methods:

  • Review of existing literature on vaccination in allergic populations.
  • Case evaluation of children with suspected vaccine reactions.
  • Analysis of evidence linking vaccination to allergic disease onset.

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

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Last Updated: Jun 19, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Main Results:

  • Children with allergies require immunization.
  • Allergic reactions to vaccine components can occur, necessitating allergist evaluation.
  • No evidence supports the claim that vaccination causes allergic diseases.

Conclusions:

  • Vaccination is safe and necessary for children with allergic diseases.
  • Individualized assessment and precautions are crucial for atopic children undergoing immunization.
  • Concerns about vaccines inducing allergic diseases are unsubstantiated by scientific evidence.