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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
Neuronal Communication01:28

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
Neuron Structure01:31

Neuron Structure

Overview

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A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA
06:53

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Published on: December 26, 2015

miRNA and neurons.

S Trivedi1, G Ramakrishna

  • 1Computational Biology Lab, Department of Zoology, JN Vyas University, Jodhpur, Rajasthan, India. svtrived@hotmail.com

The International Journal of Neuroscience
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Micro RNAs (miRNAs) regulate gene expression in neurons, with specific roles in development and mature synapses. miRNA dysfunction is linked to neurodegenerative disorders, highlighting their critical importance.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Micro RNAs (miRNAs) are key endogenous noncoding RNAs regulating gene expression.
  • Their spatial and temporal roles in neuronal gene regulation are increasingly recognized.

Purpose of the Study:

  • To review miRNA biogenesis and mechanisms of action in neurons.
  • To highlight the link between miRNA dysfunction and neurodegenerative diseases.
  • To identify unanswered questions in miRNA research.

Main Methods:

  • Literature review of studies on miRNA expression and function in neuronal development and mature states.
  • Analysis of research connecting miRNA dysregulation to neurodegenerative disorders.

Main Results:

  • miRNAs exhibit diverse expression patterns during neuronal differentiation, maturation, and synaptic function.
  • Evidence strongly associates miRNA dysfunction with the pathogenesis of neurodegenerative disorders.

Conclusions:

  • miRNAs are critical regulators of neuronal gene expression with implications for neurological health.
  • Further research is needed to fully elucidate miRNA biogenesis and their complex regulatory roles in the nervous system.