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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Video

Updated: Jun 19, 2026

Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Chromosome instability on children with asthma.

Theodore Lialiaris1, Aggeliki Polyzou, Panagiotis Mpountoukas

  • 1Department of Genetics, Demokrition University of Thrace, Alexandroupolis, Greece. lialiari@med.duth.gr

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|October 30, 2009
PubMed
Summary

Asthma patients show increased genetic instability, specifically higher sister chromatid exchanges (SCEs), indicating potential DNA damage. This suggests a new diagnostic approach for asthma focusing on genotoxic effects.

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Published on: March 10, 2016

Area of Science:

  • Genetics
  • Immunology
  • Environmental Health

Background:

  • Asthma is a complex respiratory condition influenced by genetic and environmental factors.
  • Understanding the cellular and genetic underpinnings of asthma is crucial for effective management.

Purpose of the Study:

  • To investigate genetic instability in children with asthma.
  • To assess cytostaticity and cytotoxicity in asthmatic patients' lymphocytes.

Main Methods:

  • Cultured peripheral blood lymphocytes from 18 asthmatic children and 9 healthy controls.
  • Assessed spontaneous sister chromatid exchanges (SCEs) and proliferation rate index (PRI).
  • Evaluated mitomycin C (MMC) induced SCEs to determine genotoxic effects.

Main Results:

  • Asthmatic patients exhibited a significant increase in spontaneous SCEs frequency compared to controls.
  • No significant difference in spontaneous proliferation rate index (PRI) was observed between groups.
  • MMC induced higher SCEs rates in asthmatic patients than in controls, indicating heightened sensitivity to genotoxic agents.

Conclusions:

  • Asthma is associated with increased genetic instability in peripheral lymphocytes.
  • Genotoxic, cytostatic, and cytotoxic effects of asthma can be evaluated in lymphocytes.
  • This study proposes a novel diagnostic approach for assessing asthma-related genetic instability.