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Related Concept Videos

Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Related Experiment Video

Updated: Jun 19, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Endothelial damage and autoimmune diseases.

Mariana J Kaplan1

  • 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Autoimmunity
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

This review covers how systemic autoimmune diseases cause vascular damage. It also explores how abnormal angiogenesis in these conditions contributes to tissue damage and early vascular disease.

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Last Updated: Jun 19, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
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Area of Science:

  • Immunology
  • Vascular Biology
  • Pathophysiology

Background:

  • Systemic autoimmune diseases are characterized by immune system dysregulation leading to widespread inflammation.
  • Vascular damage is a significant complication, contributing to morbidity and mortality in these conditions.

Discussion:

  • Mechanisms underlying vascular injury in autoimmune settings are complex, involving inflammatory mediators and immune cell infiltration.
  • Abnormalities in angiogenesis, the formation of new blood vessels, are increasingly recognized as a key factor in autoimmune disease pathogenesis.
  • The interplay between autoimmunity, inflammation, and vascular remodeling is crucial for understanding disease progression.

Key Insights:

  • Autoimmune processes directly trigger vascular damage through immune-mediated pathways.
  • Dysregulated angiogenesis in autoimmune diseases can lead to both tissue damage and accelerated atherosclerosis.
  • Understanding these mechanisms offers potential therapeutic targets for preventing vascular complications.

Outlook:

  • Further research into the specific molecular pathways of autoimmune-driven vascular damage is warranted.
  • Targeting angiogenic pathways may offer novel strategies for managing vascular complications in autoimmune diseases.
  • Longitudinal studies are needed to better correlate angiogenic abnormalities with clinical outcomes in patients with autoimmune conditions.