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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

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Related Experiment Video

Updated: Jun 19, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Multiple sclerosis survival: a population-based study in Sicily.

P Ragonese1, P Aridon, M A Mazzola

  • 1Department of Clinical Neurosciences, University of Palermo, Palermo, Italy.

European Journal of Neurology
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) patients face a significantly higher mortality risk compared to the general population. This increased risk is linked to disease complications and advanced age, with no observed gender disparity.

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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Last Updated: Jun 19, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Population-based survival data for multiple sclerosis (MS) is limited.
  • Previous surveys identified MS patients in Sicily.

Purpose of the Study:

  • To investigate survival rates in multiple sclerosis patients.
  • To compare mortality risks between MS patients and a matched control group.

Main Methods:

  • Matched cohort study design comparing 194 MS patients with 388 referent subjects.
  • Data collection included living status, date of death, and causes of death from municipality records.
  • Kaplan-Meier survival analysis and Hazard Ratios were used to assess mortality differences.

Main Results:

  • MS patients exhibited a 1.81-fold increased mortality risk (95% CI 1.36-2.40) compared to referents.
  • The mean age at death was significantly lower for MS patients (55.5 years) than for referents (64.8 years).
  • Higher mortality among MS patients was statistically significant (P < 0.001).

Conclusions:

  • Confirms elevated mortality risk in multiple sclerosis patients.
  • Identifies disease complications and advanced age as primary causes of death.
  • No significant gender-based differences in mortality risk were found.