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Updated: Jun 19, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Insights into gliomagenesis: systems biology unravels key pathways
Sandro J de Souza1, Beatriz Stransky, Anamaria A Camargo
1Ludwig Institute for Cancer Research, São Paulo branch, Rua João Julião 245, 1 andar, São Paulo, 01323-903, Brazil. sandro@ludwig.org.br.
Abstract:
Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterations that drive the genesis of a tumor. Recently, a systems biology approach has been used to characterize such alterations and find associations between them and the process of gliomagenesis. Here, we discuss some implications of this strategy for the development of new therapeutic and diagnostic protocols for cancer.
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